Strabismus and lazy eye

WHAT IS STRABISMUS AND LAZY EYE?

Strabismus is a visible misalignment of the eyes, with one eye turning in, out, up, down or at an oblique angle. Strabismus misalignment of the eyes can occur in some or all directions of gaze and can result in diplopia (double vision) or amylopia (lazy eye).

Early diagnosis of strabismus is essential in preventing irreversible vision loss later in life. Strabismus treatment aims to improve the alignment of the eyes and to correct the resulting vision loss (amblyopia). Amblyopia is regarded clinically as a 2-line difference from best corrected visual acuity in a structurally healthy eye.

Strabismus is one of the most common eye conditions  affecting up to 5% of the Australian population. Prisms are used to measure the degree of the strabismus and double vision.

All of the muscles in each eye must be coordinated by the brain for binocular vision to function


Complex neural networks which link numerous structures. Interactions exist between these structures within each system separately, as well as between both systems. The ideal is for the best possible acuity of each eye, binocular (stereoscopic) vision, alignment of the eyes and accurate movements and saccades
Strabismus may have sensory and/or motor origins from the peripheral and/or central nervous sysyem (brain and spinal cord ) Peripheral origin is at the level of the oculomotor muscles themselves or their innervation.

Often the  squint or lazy eye  at birth,has its extraocular muscle imbalance associated with uncorrected hypermetropic refractive error.

In this type of strabismus, when the child focuses the eyes to see clearly, the eyes turn inward. This crossing may occur when focusing at a distance, up close or both.

Such  uncoordinated eye movements can induce  vision loss as well as loss of depth perception

New strabismus in a school-aged child or adult necessitates further neurological investigations and medical history such as malignancy or autoimmune conditions, exposures, vaccinations,fever, trauma particularly to the head, orbit or periorbital area

Signs such as gait disturbance, nystagmus, decreased visual acuity or diplopia is relevant. The pattern of symptoms is important, such as whether the strabismus is constant or intermittent. If intermittent, consider whether the symptoms have been changing in frequency, and whether they are dependent on direction of gaze, or exaggerated by fatigue

How is stabismus diagnosed.

These muscle imbalances can be best diagnosed by the Hess Screen the latest versions of which can be conducted by computer technology.

• Inward turning is called esotropia

• Outward turning is called exotropia

• Upward turning is called hypertropia

• Downward turning is called hypotropia.

Other classifications of strabismus include:

• The frequency with which it occurs—either constant or intermittent

• Whether it always involves the same eye—unilateral

• If the turning eye is sometimes the right eye and other times the left eye—alternating.

Typically, constant large-angle strabismus does not cause symptoms such as eye strain and headaches because there is virtually no attempt by the brain to straighten the eyes.  Large-angle strabismus usually causes severe amblyopia in the turned eye if left untreated.

Wheras  less noticeable cases of small-angle strabismus are more likely to cause disruptive visual symptoms, especially if the strabismus is intermittent or alternating.

In addition to headaches and eye strain, symptoms may include an inability to read comfortably, fatigue when reading and unstable or “jittery” vision. If small-angle strabismus is constant and unilateral, it can lead to significant amblyopia in the misaligned eye.

Ocular deviation may be manifest (tropia) or latent (phoria). Manifest ocular deviation can be present in all directions of gaze (comitant) or only present in specific directions of gaze (incomitant) 

Concomitant deviations are relatively common. They are usually associated with hypermetropia or the anomalous placement of one or more of the extraocular muscles.

Incomitant deviations are usually caused by a functional anomaly of one or more of the extra-ocular muscles or their associated neurology. This may be a result of a defective muscle or mechanical interference in the orbit (myogenic), or a consequence of a lesion in the nerves supplying the musclature (neurogenic).

The presence of diplopia usually suggests that the incomitancy is of recent origin and indicates a disturbance to some component of the oculomotor system. This may have been caused by trauma or may indicate the presence of an intracranial tumour, aneurysm or haemorrhage.

A detailed analysis of the oculomotor fields can be obtained using the  Hess  screen (Thomson Hess Pro on PC). 

This is more effective and accurate than standard  screening tests:

Light reflex test :  The position of the light’s reflection in each of the  eyes is compared.  Deflection of the light reflex indicates abnormal ocular alignment, with each 1 mm of deflection equivalent to 15–20 prism diopters deviation  

The red reflex test:  Comparison of the red reflex of both eyes simultaneously and noting asymmetries.

Cover and Uncover tests: Eye movements by the subject patient are compared.

However the Hess results of the plots for the left and right eyes,are the gold standard as they indicate which eye has a palsied muscle and provides an index for monitoring the progression of an incomitant deviation.

Motility is tested normally in nine positions of gaze for each eye but can be done in 25 positions of gaze. The grid can be specified in units of degrees or prism dioptres.A prism dioptre corresponds to a deviation of 1 cm at 1 metre, which is equivalent to 0.573 degrees.

Primary causes of strabismus and secondary causes of strabismus can exist further to : 

Congenital syndromes Cranial nerve palsies (CNIII, IV, VI) 

Orbital fracture

Intracranial bleed

Intracranial/intraorbital/intraocular mass (benign or malignant)

Intracranial infection

Grave’s disease

Myasthenia gravis

Diabetes mellitus

Toxins and heavy metal poisoning

Post-vaccination

Fevers

muscles of human eye

Six eye muscles, controlling eye movement, are attached to the outside of each eye. In each eye, one muscle moves in the eye to the right, and one muscle moves the eye to the left. The other four muscles move it up or down and at an angle.

To line up and focus both eyes on a single target, all of the muscles in each eye must be balanced and working together. In order for the eyes to move together, the muscles in both eyes must be coordinated. The brain controls these muscles.

With normal vision, both eyes aim at the same spot. The brain then combines the two pictures into a single, three-dimensional image. This three-dimensional image gives us depth perception.

What are the symptoms of strabismus

How is vision affected?

Good vision develops during childhood when both eyes have normal alignment. Strabismus may cause reduced vision, or amblyopia, in the misaligned eye.

 Strabismic amblyopia occurs in approximately half of the children who have strabismus.

Amblyopia can be treated by patching or blurring the stronger eye to strengthen and improve vision in the weaker eye.  If treatment is delayed, amblyopia may become permanent. The earlier amblyopia is treated, the better the result for vision. Family history can be relevant.

If one eye becomes favoured it can become dominant and  suppress the effect of the other eye vision integrating in the brain .To stop confusion, the brain will sometimes ignore part of the image from one eye.

What are the signs and symptoms

Common signs can include closing one eye, clumsiness, an unusual head position,misaligned eyes , double or blurred vision and difficulty reading.

It is normal for a baby’s eyes to look misaligned for short periods of time up to the age of four months but full assesment is required.

Strabismus is especially common among children with disorders that may affect the brain, such as:

Cerebral palsy
Down syndrome
Hydrocephalus
Brain tumors
Prematurity

baby squint

How is strabismus treated ?

Treatment aims to improve the alignment of the eyes and to bring back, or protect, normal vision. Treatment can include glasses,prisms,patching or blurring of one eye, eye drops, eye muscle surgery or botulinum toxin which can alter effects of eye muscles  and eye exercises.

Genetics and family history are relevant.  If you or your spouse has strabismus, your children have a greater risk of developing strabismus as well. 

In some cases of intermittent and small-angle strabismus, it may be possible to improve eye alignment non-surgically with vision therapy.

For example, convergence insufficiency (CI) is a specific type of intermittent exotropia in which the eyes usually align properly when viewing a distant object, but fail to achieve or maintain proper alignment when looking at close object, such as when reading, resulting in one eye drifting outward. Convergence insufficiency can interfere with comfortable reading, causing eye strain, blurred vision, double vision and headaches.

 Children with exotropia (including convergence insufficiency) at an early age were significantly more likely to develop attention deficit hyperactivity disorder (ADHD), adjustment disorder and learning disabilities by early adulthood.

Certain types of exotropic  strabismus also have been associated with an increased risk of myopia but  vision therapy combined with eye exercises can help.

In children who are born with strabismus, it can be due to muscles or nerves not developing correctly, but if it appears in the first few months of life, it is usually due to the brain not controlling eye alignment correctly. Children who have a problem with the focus of their eyes, especially those who are longsighted, can develop strabismus. Strabismus can also appear after head injuries or illnesses that cause weakness in eye muscles.

In strabismus surgery, one or more of the eye muscles are strengthened, weakened or moved to a different position by permanent or adjustable suture to improve alignment.  

 Patching or blurring the strong eye to improve amblyopia (development of lazy eye due to lack of stimulation) is often necessary.  For accommodative esotropia, glasses reduce the focusing effort and often straighten the eyes. Sometimes bifocals are needed for close work.

Sometimes with  a wide, flat nose the  fold of skin at the inner eyelid can make eyes appear crossed. This appearance of pseudostrabismus may improve as the child grows. 

Adults who develop strabismus suddenly often have double vision because their brains have already learned to receive images from both eyes and cannot ignore the image from the turned eye. A child generally does not see double.

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